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mutation disease patient alzheimer polymorphism family allele study control analysis association sequence genotype linkage region onset presenilin frequency psen 1 duijn table genet early-onset dementia haplotype sample ps -2 intron protein promoter chromosome broeckhoven early-onset ad autosomal ncstn presenile van duijn group 7 q 36 linkage disequilibrium cruts m presenile ad cases marker population-based family 1270 sequencing genetic individual population-based study amyloid number presenile ad variation hofman van duijn cm backhovens h mutation analysis department research rotterdam 182ex coding early-onset alzheimer alzheimer disease family history intron 8 polymorphism psen 1 mutations onset age candidate region restriction paxip flanders interuniversity institute 2823 i /d university intronic netherland novel allele frequencies sscp analysis subject
9 Most Recent Publications
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Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
(Article)
Rijk, P. de Cruts, M. Swieten, J.C. van Aulchenko, Y.S. Rademakers, R. Broeck, M. van den Broeckhoven, C. van Sleegers, K. Dermaut, B. Theuns, J. Weckx, S. Duijn, C.M. van Pooter, T. Corsmit, E. Del-Favero, J. |
2005-01-01
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Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family
(Letter To Editor)
Rademakers, R. Broeck, M. van den Sleegers, K. Duijn, C.M. van Broeckhoven, C. van Cruts, M. |
2004-02-01
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Early cognitive decline is associated with prion protein codon 129 polymorphism
(Letter To Editor)
Croes, E.A. Dermaut, B. Houwing-Duistermaat, J.J. Broeck, M. van den Cruts, M. Breteler, M.M.B. Hofman, A. Broeckhoven, C. van Duijn, C.M. van |
2003-08-01
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The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
(Article)
Dermaut, B. Theuns, J. Broeckhoven, C. van Sleegers, K. Hasegawa, H. Vennekens, K. Corsmit, E. St George-Hyslop, P.H. Cruts, M. Duijn, C.M. van Broeck, M. van den |
2002-01-01
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Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
(Article)
Cruts, M. Dermaut, B. Rademakers, R. Roks, G. Munteanu, G. Duijn, C.M. van Broeck, M. van den Broeckhoven, C. van |
2001-11-02
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Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression
(Article)
Theuns, J. Del-Favero, J. Dermaut, B. Duijn, C.M. van Serneels, S. Corsmit, E. Cruts, M. Backhovens, H. Broeck, M. van den Broeckhoven, C. van |
2000-01-01
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Mutation screening of the tau gene in patients with early-onset Alzheimer's disease
(Article)
Roks, G. Dermaut, B. Cruts, M. Heutink, P. Julliams, A. Backhovens, H. Broeck, M. van den Serneels, S. Hofman, A. Broeckhoven, C. van Duijn, C.M. van |
1999-12-24
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Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease
(Article)
Duijn, C.M. van Cruts, M. Theuns, J. Gassen, G. van Backhovens, H. Broeck, M. van den Wehnert, A. Serneels, S. Hofman, A. Broeckhoven, C. van |
1999-10-01
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Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease
(Article)
Cruts, M. St George-Hyslop, P.H. Broeckhoven, C. van Hofman, A. Duijn, C.M. van Wehnert, A. Serneels, S. Sherrington, R. Hutton, M. Hardy, J. Backhovens, H. Broeck, M. van den |
1998-01-01
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