Wiegant, W.

artemi patient mutation artemis gene mutations fibroblast protein rs-scid artemis gene recombination coding 2 rs-scid patients rs-scid patients expression rearrangement erasmus mc /university b-cell precursor analysis blood formation signal artemis protein rag gene mutations precursor b-cell compartment figure deletion position wt artemis expression disease center rotterdam 5 rs-scid patients repair dna double-strand coding joints vh-jh gene rearrangements cyig pre-b-i cells cyig pre-b-ii cells joint missense mutations 4 rs-scid patients leukemia sample control domain center signal joints radiation point mutation assay homology differentiation department ligase netherland dna ligase iv number igh gene rearrangements activity precursor b cells b-cell differentiation arrest lymphocytes van dongen jjm arrest pre-b-i blot analysis rag mutations bm samples defect volume genomic deletion rag genes artemis mutations table point linearized dna microhomology rag 1 sensitivity sequence cytometric