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disease mutation patient study allele polymorphism family alzheimer control genet genotype analysis linkage association region frequency group protein sequence table marker university duijn presenilin genetic dementia number haplotype department cancer onset editor individual chromosome sample prion letter result psen 1 score early-onset research population linkage disequilibrium testing rotterdam model syndrome locus effect intron van duijn hearing ncstn broeckhoven cjd patients hofman van duijn cm 7 q 36 autosomal variation promoter subject population-based early-onset ad creutzfeldt –jakob disease 1555g mutation cruts m carrier family 1270 phenotype lod score alzheimer disease health american society institute evidence rotterdam study primer candidate
10 Most Recent Publications
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Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
(Article)
Rijk, P. de Cruts, M. Swieten, J.C. van Aulchenko, Y.S. Rademakers, R. Broeck, M. van den Broeckhoven, C. van Sleegers, K. Dermaut, B. Theuns, J. Weckx, S. Duijn, C.M. van Pooter, T. Corsmit, E. Del-Favero, J. |
2005-01-01
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Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease
(Article)
Croes, E.A. Alizadeh, B.Z. Duijn, C.M. van Bertoli Avella, A.M. Rademaker, T.A.M. Vergeer-Drop, J. Dermaut, B. Houwing-Duistermaat, J.J. Wientjens, D.P.W.M. Hofman, A. Broeckhoven, C. van |
2004-05-01
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Early cognitive decline is associated with prion protein codon 129 polymorphism
(Letter To Editor)
Croes, E.A. Dermaut, B. Houwing-Duistermaat, J.J. Broeck, M. van den Cruts, M. Breteler, M.M.B. Hofman, A. Broeckhoven, C. van Duijn, C.M. van |
2003-08-01
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The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
(Article)
Dermaut, B. Theuns, J. Broeckhoven, C. van Sleegers, K. Hasegawa, H. Vennekens, K. Corsmit, E. St George-Hyslop, P.H. Cruts, M. Duijn, C.M. van Broeck, M. van den |
2002-01-01
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Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease
(Article)
Cruts, M. Dermaut, B. Rademakers, R. Roks, G. Munteanu, G. Duijn, C.M. van Broeck, M. van den Broeckhoven, C. van |
2001-11-02
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Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-jakob Disease phenotype
(Article)
Everbroeck, B. van Croes, E.A. Pals, P. Dermaut, B. Jansen, G. Duijn, C.M. van Cruts, M. Broeckhoven, C. van Martin, J-J. Cras, P. |
2001-11-02
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Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease
(Article)
Dermaut, B. Roks, G. Breteler, M.M.B. Theuns, J. Rademakers, R. Houwing-Duistermaat, J.J. Serneels, S. Hofman, B. Cruts, M. Broekchoven, C. van Duijn, C.M. van |
2001-11-01
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The Cystatin C polymorphism is not associated with early-onset Alzheimer's disease.
(Article)
Roks, G. Cruts, M. Slooter, A.J.C. Dermaut, B. Hofman, A. Broeckhoven, C. van Duijn, C.M. van |
2001-01-01
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Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia
(Article)
Croes, E.A. Dermaut, B. Duijn, C.M. van Cammen, T.J.M. van der Broeckhoven, C. van |
2000-01-01
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Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression
(Article)
Theuns, J. Del-Favero, J. Dermaut, B. Duijn, C.M. van Serneels, S. Corsmit, E. Cruts, M. Backhovens, H. Broeck, M. van den Broeckhoven, C. van |
2000-01-01
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