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Falany, C.N.
( C.N. Falany)
sult 1e e 2 sulfation sulfation phah-oh library erasmus mc inhibition sulfotransferase estrogen liver hydroxylated ic 50 values effect compound value erasmu sult 1a result estrogen sulfotransferase liver cytosol downloaded library metabolite falany cytosolic inhibitor 30- min incubation hydroxy substrate structure reaction conditions hydroxyl group table pcdf-oh falany cn hormone cancer endocrinol enzyme pcdd-oh hydroxylated metabolites concentration protein sulfated group cytosol analysis metab 0.1 polychlorinated experiment kester estrogenic toxicol thyroid hplc analysis estrogenic effects reaction november health sulfated products chlorine substituents activity sult 1e inhibition product visser sult 1e activity study hydroxylated phah metabolites method condition breast cancer risk substituent cytosolic sulfotransferases hydroxyl core structure km value december tissue hydroxylated phahs incubation
3 Most Recent Publications
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Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters
(Article)
Kester, M.H.A. Visser, T.J. Brouwer, A. Bulduk, S. Toor, H. van Tibboel, D. Meinl, W. Glatt, H. Falany, C.N. Coughtrie, M.W. Schuur, A.G. |
2002-01-01
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Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs
(Article)
Kester, M.H.A. Bergman, A. Falany, C.N. Coughtrie, M.W. Kuiper, G.G.J.M. Safe, S.H. Visser, T.J. Brouwer, A. Schuur, A.G. Bulduk, S. Tibboel, D. Meinl, W. Glatt, H. |
2000-01-01
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Sulfation of thyroid hormone by estrogen sulfotransferase
(Article)
Kester, M.H.A. Visser, T.J. Coughtrie, M.W. Dijk, C.H. van Tibboel, D. Hood, A.M. Rose, N.J. Meinl, W. Pabel, U. Glatt, H. Falany, C.N. |
1999-01-01
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