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asparaginase patient level children treatment blood group leukemia lymphoblastic leukemia pompe disease disease study l-asp lymphocytes control pompe lymphoblastic serum protein sample childhood l-asparaginase percentage parameter asparagine expression age groups activity coagulation infusion asparaginase medac effect medac value figure induction preparation difference score thrombin generation result paronal dexamethasone table range sensitivity protocol pas-positive therapy asparaginase preparations mrna expression blood films factor diagnosis erasmu pas-positive lymphocytes number 11–16 2012-04-02 | id 1000521777 | ip signi volume glutamine l-asp sensitivity phase asparaginase treatment method fi rst dose thrombin coagulation parameters 6–10 induction treatment <0.001 change lymphocyte 1–5 thrombosis netherland day 29 fusion
