Rijntjes, E.

histamine patient provocation naniper challenge mucus production patency 400 dose control subjects 100 dose mucus production group histamine challenge control subject rhiniti study cda challenge specificity reactivity cda provocation series threshold hyperreactivity table effect cda reactivity sensitivity parameter reproducibility outcome parameters histamine provocation result symptom threshold doses provocation series method regression degree difference responsiveness reduction period outcome order response histamine challenges dose step nonallergic cutoff lines treatment effect n saline presence cutoff nonallergic noninfectious coefficient regression lines curve interval function value fokken mucosa braat noninfectiou paranasal sinus infection dose steps naniper group figure regression line analysis vasomotor rhinitis netherland cda provocation method blood cell count neurogenic reflex mechanisms 16 patients symptom scores change score