Berkhoff, E.G.M.

virus epitope influenza influenza virus response substitution fluenza t-cell cytotoxic influenza viruses hla-b acid substitutions infection assay sequence clone mutation recognition virus-specific cytotoxic t lymphocytes protein variant target cells target fluenza virus peptide r 384g substitution ctl epitopes rimmelzwaan population np 418-426 epitope 418-426 residue study osterhau virol variation pbmc cultures position fitness figure immunol culture plasmid anchor residues lytic activity number fi tness hla-a result fouchier effect nucleoprotein speci fluenza viruses subject 383-391 anchor class ctl response r 384g mutation 293 t cells virus-speci antigen np 383-391 epitope activity control lymphocytes acid substitution percentage effector cells np 383391 epitope virus-specific ctl response stimulation mdck cells replication reduction virus ctl epitopes anchor residue antibody