Brakenhoff, J.P.

patient glucosidase disease enzyme virus influenza muscle treatment cr 6261 animal antibody glycogen study tissue enzyme replacement therapy group pompe disease challenge therapy rabbit glucosidase activity activity pompe control 4 patients efficacy control group storage month rhaglu heart lysosomal production rhgaa rabbit milk replacement figure reuser rotterdam weight infection effect h 5n virus 40 mg /kg injection netherland ko mice protein table model h 5n challenge development 20 mg /kg infusion temperature deficiency influenza viruses panel control animals precursor infant 30 mg /kg pandemic change alpha-glucosidase mutation c 57bl mice muscle function 4 years erasmus mc-sophia liver function glycogen content body temperature body weight 1 year 12 weeks result reuser aj administration