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Hirtum, H. van
( H. van Hirtum)
patient glucosidase enzyme disease muscle treatment glycogen enzyme replacement therapy pompe disease tissue therapy rabbit glucosidase activity activity pompe study 4 patients storage month rhaglu heart lysosomal production rhgaa rabbit milk replacement reuser antibody rotterdam effect 40 mg /kg injection ko mice protein table development 20 mg /kg infusion deficiency precursor infant netherland alpha-glucosidase mutation c 57bl mice muscle function 4 years erasmus mc-sophia liver function glycogen content 1 year 12 weeks reuser aj baseline titer fabry disease patient 3 van der ploeg glycogen storage erasmu 110- kda precursor section motor gsdii efficacy genetic a.j.j inclusion patients 1 lysosomal glycogen quadriceps muscle mouse patient 1 hypertrophy acid alpha-glucosidase 3 months enzyme administration +++ number
2 Most Recent Publications
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Long-term intravenous treatment of Pompe disease with recombinant human alpha-glucosidase from milk
(Article)
Hout, J.M.P. van den Sibbles, B. Corven, E.J. van Hirtum, H. van Kamphoven, J.H.J. Ploeg, A.T. van der Hove, J. van Arts, W.F.M. Doorn, P.A. van Klerk, J.B. de Loonen, M.C.B. Vulto, A.G. Brakenhoff, J.P. Kroos, M.A. Hop, W.C.J. Winkel, L.P.F. Jong, G. de Cromme-Dijkhuis, A.H. Weisglas-Kuperus, N. Reuser, A.J.J. Boer, M. Smeitink, J.A. Diggelen, O.P. van Voort, E. van der |
2004-01-01
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Human acid alpha-glucosidase from rabbit milk has therapeutic effect in mice with glycogen storage disease type II
(Article)
Bijvoet, A.G. Reuser, A.J.J. Ploeg, A.T. van der Hirtum, H. van Kroos, M.A. Kamp, E.H. van de Schoneveld, O. Visser, P. Brakenhoff, J.P. Weggeman, M. Corven, E.J. van |
1999-01-01
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