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Bottardi, S.

( S. Bottardi)

erythroid cells globin promoter erythroid histone locus hu ␤ promoter ␤- globin locus figure chromatin acetylation marrow mouse expression region recombination tg-hu plasmid clone dnase control blood level assay ach 3 cd 34ϩ cells tg-hu ␤ promoter ln 2 hpcs activation bone marrow vector analysis ﬁcation bone marrow cells acetylated result e.coli sequence histone acetylation dnase i sensitivity speci ﬁc pac 148 pattern erasmus mc histone modi ﬁcations hematopoietic regulation transcription speci globin genes dnase i colony frequency sensitivity selection hematopoietic progenitor cells sample method bone marrow hpcs globin gene expression dnase i digestion modification adult integration ncoi site chip assays liver rt-pcr hematopoiesi mol cell mol cell biol acids research hu ␤ gene hu ␥ promoters pd 3lox progenitors c-kit plasmid pd 3lox beta-globin type i

2 Most Recent Publications

Developmental stage-specific epigenetic control of human beta globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation. (Article) Bottardi, S. Aumont, A. Grosveld, F.G. Milot, E.	2003-01-01
Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli (Article) Patrinos, G.P. Krom, M. de Bottardi, S. Janssens, R.J. Katsantoni, E. Wai, A.W. Sherratt, D.J. Grosveld, F.G. Imam, A.M.A.	2000-01-01

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