Kettelhack, C.

patient tumor sarcoma perfusion tissue limb perfusion cancer necrosis tissue sarcomas extremity response melphalan tumor necrosis factor toxicity resection grade therapy treatment tissue sarcoma effect result 186 patients melanoma schraffordt koops h amputation factor recurrence radiation radiation therapy eggermont oncol level month center preoperative antitumor effects study extremity sts preoperative radiation therapy eggermont amm disease control procedure antitumor tumor remnant phase metastase chemotherapy tnf-a score lienard others ann experience isolation perfusion table range pressure outcome histologic 55 patients leakage series tumor size combination blood regression isolation remnant trial survival limb perfusions model schraffordt monitoring blood pressure cancer patients recurrence rates doxorubicin observation netherland