Roos, W.K. de

tumor perfusion vector adenoviral vectors luciferase limb perfusion tissue administration transfer luciferase activity intratumoral activity adenoviral delivery cancer expression tumor tissue organ intratumoral injection tumor cells therapy injection gene transfer study factor tumor necrosis factor hum gene minute virus circuit luciferase gene expression luciferase marker gene sarcoma adenovirus-mediated gene transfer 6 gene therapy necrosis tumor-specific ig.ad.mlp.luc melphalan 30 minutes 1 109 netherland target cells tumor specificity vessel intratumoral administration marker adenoviruse animal anticancer gene therapy system specificity 15 minutes melanoma gene therapy figure adenovirus-mediated gene delivery patient gene expression leakage vasculature needle track muscle -175 promoter liver infusion needle diameter transfected technique eggermont model tumor-specific gene delivery tumor vasculature suicide genes protein others ann femoral artery