Manusama, E.R.

tumor perfusion necrosis melphalan tumor necrosis factor patient effect sarcoma cancer factor model limb perfusion tissue response study group treatment combination antitumor result hemorrhagic necrosis melanoma administration diameter tumor response activity vessel netherland tumor cells platelet figure necrosectomy osteosarcoma step-up approach toxicity tissue sarcomas chemotherapy schraffordt koops h antitumor effect growth tumour necrosis factor university pancreatitis hemorrhagic tumor regression extremity lienard center platelet aggregation therapy regression tumor growth step-up approach bn 175 sarcoma blood animal agent surgery necrotizing pancreatitis eggermont organ lejeune aggregation concentration tumor vasculature vector adenoviral vectors luciferase drainage isolation isolation perfusion tumor necrosis antitumor effects tissue sarcoma disease rotterdam vasculature lejeune fj response rate