Goor, M.L. van

tobramycin combination ceftazidime therapy regimen synergism antibiotic concentration t 0 h monotherapy combination therapy agents chemother combination therapy regimens aeruginosa strain curve agent model pseudomonas aeruginosa pseudomona chemother antimicrob experiment aeruginosa cf 133 method aukc 0-24h t 24 h /liter study resistance pharmacokinetic 103 cfu /ml dosing monotherapy regimen combination therapy schedules dosing regimens q 24h peak concentration dilution difference t 8 h 0-24h 0.1 growth checkerboard effect time-kill curves pharmacokinetic model time-kill antibiotic concentrations monotherapy regimens titration control growth curve inoculum infection table patient t 20 min ceftazidime q 8h cfu /ml logarithmic culture bactericidal activity administration netherland analysis q 8h tobramycin combination agent exposure mechanism checkerboard titration aminoglycoside control hollander nonsimultaneous administration mouton sample trough concentrations neutropenic rats 64 mg /liter aminoglycoside-modifying enzymes