Festen, J.E.

aerosol children study particle inhalation facemask spacer delivery therapy deposition filter inhalation therapy nebulizer administration inhaled child chapter aerosol delivery airway effect patient pattern lung dose breathing respir particle size score aerosol loss pmdi-spacer drug delivery efficacy aerosol therapy cooperation efficiency filter dose variability infant design figure filter dose volume asthma device lung deposition symptom combination factor result output filter doses hans rudolph mask aerosol particles 1.5 spacer output method astrazeneca pharmacokinetic budesonide variability pediatr facemask design aerosol administration inhaler side effects position model life study jongste jc erasmu tidden breathing pattern medication procedure 2.5 treatment jongste 2.5 m galemed concentration nebuchamber adult