Nollau, P.

infant flt 3 patient pkc 412 sample leukemia mutation expression flt 3 expression infant mll samples infant mll patients infant mll blood level flt 3 phosphorylation germline mll genes activation inhibitor study kinase flt 3 inhibition receptor infant mll cells leukemic cells noninfant figure wild-type flt 3 flt 3l expression inhibition leukemic myeloid leukemia cytotoxic response tyrosine flt 3 gene concentration lymphoblastic lymphoblastic leukemia analysis cytotoxic wild-type flt 3 inhibitors mll gene rearrangements 3/itd group jm domain rearrangement phosphorylation activation loop response domain children flt 3. invitrogen life technologies activation loop mutations pkc 412. flt 3 mutations flt 3/itds pkc 412 concentrations pkc 412 cytotoxicity hospital presence myeloid tandem childhood 412. sensitivity leukemic-cell death difference tandem duplication duplication germline santa cruz biotechnology sequence death overexpression cytotoxicity translocation drug resistance target volume