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patient infant leukemia group expression study sample lymphoblastic leukemia treatment blood lymphoblastic children mll-rearranged mll-rearranged infant month figure analysis level signi rearrangement interfant gene expression outcome fication cancer number flt 3 erasmus mc methylation translocation relapse response prednisone protocol concentration probe result signi ficantly pharmacokinetic flt 3 expression survival lymphoblastic leukaemia erasmu ficantly trial 1 year prednisolone diagnosis breakpoint fusion mll rearrangements pkc 412 daunorubicin prognostic resistance table phase volume model hospital leukaemia -99 signature clearance remission mutation induction marrow library interfant -99 protocol article therapy probe sets childhood dna methylation chemotherapy methotrexate germline death 2011.
10 Most Recent Publications
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Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: Results from the Interfant-99 Study
(Article)
Mann, G. Attarbaschi, A. Szczepański, T. Ferster, A. Janka-Schaub, G.E. Rubnitz, J.E. Silverman, L.B. Stary, J. Campbell, M. Li, C.K. Suppiah, R. Biondi, A. Schrappe, M. Vora, A. Valsecchi, M.G. Pieters, R. Lorenzo, P. de Peters, A.C.B. Hann, I. Rossi, G. de Felice, M. Lausen, B. Leblanc, T.M. |
2010-10-14
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Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants
(Article)
Stam, R.W. Schneider, P. Hagelstein, J. Linden, M.H. van der Stumpel, D.J.P.M. Menezes, R.X. de Lorenzo, P. de Valsecchi, M.G. Pieters, R. |
2010-04-08
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Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia treatment
(Article)
Jung, R. Jacobs, U. Teigler-Schlegel, A. Panzer-Gruemayer, E.R. Dongen, J.J.M. van Schrappe, M. Boer, M.L. den Pieters, R. Rascher, W. Metzler, M. Krumbholz, M. Langer, T. Keller, T. Lorenzo, P. de Valsecchi, M.G. Velden, V.H.J. van der Moericke, A. Stanulla, M. |
2010-04-01
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Pharmacokinetics of daunorubicin and daunorubicinol in infants with leukemia treated in the interfant 99 protocol
(Article)
Hempel, G. Relling, M.V. Rossi, G. de Stary, J. Lorenzo, P. de Valsecchi, M.G. Barisone, E. Boos, J. Pieters, R. |
2010-03-01
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Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
(Article)
Stam, R.W. Boer, M.L. den Pieters, R. Schneider, P. Boer, J.B. de Hagelstein, J. Valsecchi, M.G. Lorenzo, P. de Sallan, S.E. Brady, H.J.M. Armstrong, S.A. |
2010-02-04
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Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
(Article)
Stumpel, D.J.P.M. Schneider, P. Roon, E.H.J. van Boer, J.M. Lorenzo, P. de Valsecchi, M.G. Menezes, R.X. de Pieters, R. Stam, R.W. |
2009-12-24
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Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol
(Article)
Linden, M.H. van der Valsecchi, M.G. Rubnitz, J.E. Stary, J. Szczepański, T. Vora, A. Ferster, A. Hovi, L. Silverman, L.B. Pieters, R. Lorenzo, P. de Möricke, A. Janka, G. Leblanc, T.M. Felice, M. Biondi, A. Campbell, M. Hann, I. |
2009-10-29
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Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia
(Article)
Lönnerholm, G. Valsecchi, M.G. Hann, I. Pieters, R. Lorenzo, P. de Schrappe, M. Hovi, L. Campbell, M. Mann, G. Janka-Schaub, G.E. Li, C.K. Stary, J. |
2009-05-01
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Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol
(Article)
Velden, V.H.J. van der Corral, L. Marschalek, R. Nigro, L.L. Metzler, M. Basso, G. Mann, G. Boer, M.L. den Biondi, A. Pieters, R. Dongen, J.J.M. van Valsecchi, M.G. Jansen, M.W.J.C. Lorenzo, P. de Cazzaniga, G. Panzer-Grumayer, E.R. Schrappe, M. Schrauder, A. Meyer, C. |
2009-02-13
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Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia [8]
(Article)
Stam, R.W. Schneider, P. Lorenzo, P. de Valsecchi, M.G. Boer, M.L. den Pieters, R. |
2007-10-01
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