Toledo, S.P.

patient aipmut receptor mutation control tumor adenomas endocrinol somatotropinoma group diagnosis response expression aipmut group protein library erasmus mc level metab department disease endocrinology study wild-type activity characteristic adenoma hek 293 cells gigantism phenotype leydig binding table cell surface expression aipmut cohort surface lhr gene therapy hormone aryl hydrocarbon receptor centre hydrocarbon becker symptom receptor activity binding sites vector university transfected result prolactinoma treatment leydig cell hypoplasia basal feature cohort prolactin number range leydig cells testosterone daly af tumor diameter macroadenoma extension igf-i radiotherapy adenoma predisposition population 373–e france erasmu liege aip mutations residue tumor size transfection growth 0.0 november surgery