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study allele disk degeneration degeneration association sibling bone mineral density subject body mass index population spine women osteoarthritis frequency factor number joint effect rotterdam study col 2a gene polymorphism score analysis hand roa individual rotterdam disease table hip roa density collagen mineral col 2al gene chapter disc degeneration locus referent subjects radiograph linkage rheum sample heberden index proband trait /or disk degeneration radiological osteoarthritis genotype sum score referent igf-l radiological percent sibling pair study marker estimate occurrence kellgren cartilage knee roa result haplotype evidence finding group variance genet 1hriti presence population-based method heritability sibling pairs model igf-i prevalence col 9al gene influence level hofman
6 Most Recent Publications
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Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study
(Article)
Zhai, G. Duijn, C.M. van Hofman, A. Rivadeneira Ramirez, F. Houwing-Duistermaat, J.J. Meulenbelt, I. Bijkerk, C. Meurs, J.B.J. van Uitterlinden, A.G. Pols, H.A.P. Slagboom, P.E. |
2004-01-01
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A unified approach to modelling linkage to quantitative and qualitative traits
(Article)
Houwing-Duistermaat, J.J. Bijkerk, C. Hsu, L. Slagboom, E.P. Duijn, C.M. van Stijnen, Th. |
2003-09-01
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Genetic epidemiology of osteoarthritis: Studies of familial aggregation and candidate genes
(Doctoral Thesis)
Bijkerk, C. |
1999-03-03
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Heritabilities of radiologic OA in peripheral joins and of disc degeneration of the spine
(Article)
Bijkerk, C. Houwing-Duistermaat, J.J. Valkenburg, H.A. Meulenbelt, I. Hofman, A. Breedveld, F.C. Duijn, C.M. van Slagboom, P.E. Pols, H.A.P. |
1999-01-01
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Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis
(Article)
Meulenbelt, I. Bijkerk, C. Wildt, S.C.M. de Miedema, H.S. Breedveld, F.C. Hofman, A. Duijn, C.M. van Slagboom, P.E. Pols, H.A.P. |
1999-01-01
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A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study)
(Article)
Meulenbelt, I. Bijkerk, C. Miedema, H.S. Breedveld, F.C. Valkenburg, H.A. Pols, H.A.P. Slagboom, P.E. Duijn, C.M. van Hofman, A. |
1998-01-01
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