Bogaards, A.

fluorescence imaging marker resection tissue cancer detection tumor method excitation image light brain wavelength ratio signal study model quantification therapy autofluorescence absorption wilson photodynamic therapy tumour photodynamic value bogaard animal fluorophore performance result concentration property fluorescence signal wilson bc 5- aminolevulinic acid variation blood technique parameter range emission patient treatment fluorescence imaging system surgery sterenborg application device group chapter information biopsy response surface disease aminolevulinic table image-guided surgery lilge fluorescence image target glioma image-guided volume measurement ratio fluorescence imaging change stepp h factor coefficient state correction layer research feasibility fluorescence imaging device prototype