Krom, M. de

globin expression locus deletion transcription globin genes element region histone chromatin globin locus promoter mouse factor effect activation sequence level study protein stage recombination transcriptional control result regulation fragment grosveld globin gene expression adult binding probe interaction gene expression analysis beta-globin blood erythroid globin gene ␤- globin gene globin expression hypersensitive clone enhancer transcriptional activation structure figure liver pattern activity assay foetal model chromatin structure transcript transgene number position plasmid transcription factors vector function erythroid cells nucleosome hypersensitive sites modification domain acetylation method mutation histone h 3 integration nature signal chromosome development locus control region gene activation foetal liver yolk sac