Munteanu, G.

disease mutation alzheimer van broeckhoven identi fied family linkage autosomal amyloid presenile ad cases analysis secretase protein presenile precursor duijn broeckhoven sequence cleavage polymorphism identi v 262 polymorphism population-based study family history locus population-based analyses patient ad families association hofman chromosome sample science study sequencing allele william late-onset control history protease association analysis early-onset genet 9 autosomal secretase cleavage genomic structure antwerp result bart dermaut genbank acc university ab production genotype distributions exon 5 production enzyme rosa rademakers genome sequencing effort neuroscience letter variation genomic mutation analyses department genome onset transmembrane erasmus university rotterdam presenile alzheimer disease population polymerase chain reaction netherland hutton pyrophosphate dna sequencing flanders interuniversity institute marker presence blood vessel walls dermaut