Neddermeijer, H.G.

algorithm function optimization model test functions rsm algorithms point microsimulation model nmsm algorithms microsimulation simulation response value method objective function simplex screening vertex response surface methodology parameter mead simplex method subregion error polynomial cancer nmsm algorithm objective center point iteration microsimulation models vertex x hi barton surface result evaluation methodology x refl table number simulation response function comparison john wiley stepsize 18 test functions breast cancer screening difference center deviation efficiency line search nelder design average phase accuracy algorithms rsm 2 study 0.95 0.99 vertex x refl optimization methods iteration i response function performance 20 optimization optimization algorithms function value minimization reliability approximation rsm 4 breast analysis region section stochastically level paper simulation optimization response surface function