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exposure response repair effect animal study mouse health xpc mice strain wild-type van loveren genome littermate group genome ner nucleotide excision repair damage uv exposure transcription-coupled repair loveren skin effects cancer health council model immunosuppression allergen dna damage control infection immunomodulation edema level garssen allergy suppression sensitization xeroderma pigmentosum ttd mice netherland gruijl signi uv-b-induced factor wild-type littermates council defect baltic xeroderma sensitivity pigmentosum lesion hypersensitivity radiation uv-induced excision harbor seals herring kripke patient phoca 6 itulina non-uv-exposed animals erythema ear thickness xpa mice van steeg ear challenge contact hypersensitivity dermatol 6-4 photoproducts dth responses syndrome challenge table threshold level uv-induced dna damage ficient control wild-type littermates van der leun osterhau