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g-csf-r receptor internalization g-csf figure activation socs 3 factor expression granulocyte colony-stimulating factor protein granulocyte blood stat 3 j biol chem kinase colony-stimulating wt g-csf-r antibody g-csf-rd motif wt g-csf-r /egfp panel /egfp distribution stat 5 tyrosine level result gcsfr-d 715 mice touw ip shp -2 receptor internalization recruitment domain mutation tyr 729 myeloid g-csf-rd 715 cytokine neutropenia socs 1 number minute stat 3 activation stat 5 activation inhibitor activity signal luciferase plasma membrane antig-csf-r volume region gcsfr-d ligand-mediated g-csf-r internalization 60 minutes antig-csf-r antibodies fusion dileucine internalization motif sh 2 domain residue serine mutant inhibition biotinylated mechanism g-csf-r internalization presence growth study phosphorylation socs 3 expression deletion truncation figure 6 b ligand-induced membrane bone marrow cells clone
