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receptor figure g-csfr internalization g-csf g-csf-r csf 3r expression protein factor ubiquitination activation lysine lysosomal wt csf 3r antibody panel granulocyte colony-stimulating factor kinase granulocyte level colony-stimulating endosome dub 2 domain myeloid signal control degradation endocytosi cytokine result blood motif residue membrane wt g-csfr ba /f cells 37 ◦ c tyrosine socs 3 mutant enzyme csf 3 proliferation cytoplasmic dub 2a pathway inhibitor experiment distribution ubiquitin csf 3 stimulation growth touw ip k 5r g-csfr journal deubiquitinating lys 632 activity cell-surface expression wt g-csf-r /egfp family presence k 632 study cell-surface stat 5 phosphorylation binding /egfp clone region mechanism ligase stat 5 activation wt g-csf-r stat 5 differentiation lysine residues 30 min
