Gassen, G. van

polymorphism disease alzheimer patient chromosome mutation genotype association promoter study intron early-onset allele psen 1 region chromosome 14 analysis presenilin sequence ad patients onset control promoter polymorphism early-onset ad linkage dlst gene genet intron 8 polymorphism early-onset alzheimer frequency linkage disequilibrium e 2k component psen 1. table marker family ad /b families ad /a psen 1 mutations mapping population-based study van broeckhoven promoter region duijn ad 3 gene psen 1 gene university candidate backhoven sscp analysis intron 8 exons 8 netherland 44 genotype pcr products intronic polymorphism fi nding allele 1 broeckhoven dementia dehydrogenase population-based nding series kgdhc sequencing disequilibrium variation backhovens h psen 1 mutation intron 8 association b -2610 antwerpen fi ndings sscp patterns dihydrolipoyl succinyltransferase gene onset age intronic neurosci signi ficance presenilin 1 gene