Schenk, P.W.

cisplatin yeast resistance concentration cerevisiae sensitivity doxorubicin strain creatinine patient sky 1 plasma cisplatin resistance npr 2⌬ cells disruption schenk cancer npr 2 srpk 1 sky 1 cells sky 1 gene phenotype protein study assay expression allele saccharomyces cerevisiae netherland agent i-stat level repair imi dose requirement saccharomyce result isogenic 2780 cells cyp 2d imi dose requirement sky 1p metabolizer range mutation kinase medium reflotron imipramine cisplatin-resistant cyp 2c anticancer experiment accumulation mgsc-sky 1 cells doxorubicin resistance group state mgsc-sky npr 2 gene difference cisplatin sensitivity cadmium chloride mechanism drug resistance mutator phenotype yeast cells laboratory vector treatment kruskal –wallis test blood imi doses antidepressant genotype dose unit sequence platinum as-srpk cadmium