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cisplatin resistance yeast expression cancer sensitivity platinum cerevisiae accumulation doxorubicin strain mirna oxaliplatin marker hslc 22a protein sky 1 assay cisplatin resistance npr 2⌬ cells disruption blood npr 2 srpk 1 imatinib sky 1 cells sky 1 gene uptake netherland body fluids mirna markers platinum compounds phenotype fluid concentration agent control study schenk transporter microarray rt-pcr 293/neo burger saccharomyces cerevisiae result sample mechanism hek 293/hslc cells compound figure repair mutation anticancer saccharomyce kinase isogenic semen 2780 cells experiment carboplatin 293/hslc sky 1p level taqman treatment cisplatin-resistant medium substrate mgsc-sky 1 cells doxorubicin resistance transport mgsc-sky npr 2 gene intracellular cancer cell lines mir -891a cisplatin sensitivity analysis drug resistance