Leeuwen, D. van

receptor g-csf g-csf-r factor granulocyte activation granulocyte colony-stimulating factor mutation tyrosine colony-stimulating myeloid gcsfr blood colony patient domain proliferation differentiation signal ligand neutropenia stat 3 p 206h mutation progenitor analysis marrow expression response binding p 206h wild-type growth region effect figure cytokine pathway tyr 764 tyr 729 extracellular domain clone protein concentration myeloid progenitor cells bone marrow cells number vector level survival stat 3 activation mutant study formation murine extracellular touw ip stat activation presence receptor activation activity ligand binding sites flow cytometric analysis cytoplasmic gcsfr / mice medium g-csfinduced culture kinase receptor tyrosines koning jp transduced g-csf-r wt g-csf treatment g-csf receptor replating tyr 704 myeloid cells g-csf-r tyrosines stat 5 j biol chem