Eijnden, M.M.E.D. van den

prorenin receptor angiotensin angiotensinogen renin incubation level ang ii 4 hours medium m 6p receptors binding activation schalekamp madh generation huvec ang i wild-type protein wild-type prorenin danser ahj danser intracellular saxena pr ang ii levels k /a prorenin inhibitor schalekamp synthesis hypertension j biol chem dna synthesis effect prorenin binding angiotensin ii derkx fhm internalization myocyte angiotensin generation presence j hypertens cardiomyocyte mannose phosphate result intracellular angiotensin generation van den eijnden lamers jmj m 6p prorenin incorporation figure van kats jp 4- hour incubation absence protease cell-associated saxena heart study experiment /l wild-type prorenin control derkx enzyme reudelhuber tl prosegment rat cardiomyocytes ang ii generation 3 h-thymidine incorporation verdouw pd prorenin activation growth /106 cells serum dna content cell-associated prorenin cell lysates ice-cold minute degradation