Reudelhuber, T.L.

prorenin effect receptor angiotensin heart incubation figure huvec activation progenitor cells medium wild-type 4 hours level marrow wild-type prorenin renin ang ii angiotensinogen k /a prorenin m 6p receptors progenitor number heart failure binding treatment ang i inhibitor generation bone marrow – angiotensin generation animal m 6p prorenin result schalekamp madh control protease study cell-associated failure bone marrow concentration function j biol chem group /l wild-type prorenin peptide increase angiotensin ii danser internalization intracellular enzyme infarction intracellular angiotensin generation van den eijnden heptapeptide absence c-kit van kats jp prorenin activation wt mice j hypertens danser ahj bone marrow cells walther t presence walther pressure schalekamp /106 cells bader m cell-associated prorenin cell lysates saxena pr ice-cold hypertrophy pathophysiological conditions minute degradation