Broekchoven, C. van

polymorphism disease alzheimer study presenilin association control genotype intron –48 intronic patient presenilin –1 polymorphism rotterdam study promoter presenilin –1 gene psen 1 van broeckhoven c rotterdam frequency dementia intronic polymorphism allele effect neurosci presenilin 1 gene result sample neurol late-onset effect model population cruts m presenilin –1 onset presenilin 1 analysis variation value expression meta-analysi population-based region genet case-control duijn backhovens h apolipoprotein e genotype hofman 56 apoe *4 ad patients van harskamp f odds ratio lancet van duijn cm –48 cc genotype breteler mm –48 c /t apolipoprotein intron 8 polymorphism group broeckhoven theun early-onset interaction breteler difference model linkage disequilibrium fisher p values japanese population promoter polymorphism examination alzheimer disease aa genotype table 3 times amyloid dermaut