Huisman-de Boer, J.J.

infant pharmacokinetic preterm infants serum preterm clearance day 3 level t 1/2 parameter neonate patient study body weight weight inulin body clearance 1/2 32 weeks ampicillin concentration sample birth calibration curve room temperature dosage /liter filtration penicillin trough postnatal age relationship amoxicillin curve pediatr blood inulin infusion technique serum drug levels agent laboratory parameters pharmacokinetics parameters 5 mg /liter table serum drug half-life result antimicrobial agents agents chemother 17 preterm infants dosing interval analysis infusion deviation elimination infection function increase model parenteral nutrition 17 infants 100 g birth parameter dosage recommendations antimicrobial regression 4.9 calibration trough levels 0.4 0.3 half-life 1990. temperature postnatal blood samples elimination rate birth weight 4 weeks table 1. recommendation trough level