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pressure fhh rats damage blood kidney hypertension aci rats fhl rats study blood pressure strain fawn-hooded provoost ap response level model animal development provoost fhh rat disease susceptibility increase artery myogenic fawn-hooded rat group l-name hypertensive failure control blood flow autoregulation physiol value difference jacob hj chapter dokkum effect weight myogenic response f i rats nephrol jacob van dokkum rpe vessel glomerulosclerosi 150 mmhg treatment relationship fawn-hooded rats figure proteinuria table injury transmural pressure analysis j physiol hypertensive rats mechanism excretion fhh x aci polycystic kidney disease congenic incidence change plasma filtration rate l-name-induced hypertension experiment protein brenner bm perfusion pressure result systolic blood pressure impairment resistance rennke hg l-name-induced