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treatment patient cancer trial survival prostate study prostate cancer group factor effect endpoint disease result prognostic eortc progression analysis treatment effect psa progression model prognostic factors therapy table metastatic prostate cancer irradiation metastatic difference benefit response phase value chapter number endpoints figure death androgen randomized progression-free survival radiotherapy level validation adjuvant oncol prostatectomy psa response prognostic factor increase hazard definition failure ratio radiation hazard ratio treatment effects grade marker stage follow-up baseline collette hormone androgen blockade psa endpoint antigen research phase iii month status association margin event tmprs castration progression-free power design quality criteria
