Brinkhof, B.

patient rearrangement relapse target diagnosis glucocorticoid leukemia polymorphism lymphoblastic leukemia clonal analysis childhood lymphoblastic receptor gr gene mrd-pcr targets oligoclonal mutation mrd-pcr precursor-ball van dongen jjm blood study glucocorticoid receptor gene disease glucocorticoid resistance clonal evolution resistance pattern detection variation heteroduplex pcr analysis stability response figure sequence evolution product table sensitivity tcrg gene rearrangements result allele children primers heteroduplex configuration dongen igh gene rearrangements pcr products body mass index region gene rearrangements population heteroduplex analysis immunoglobulin prednisone vivo prednisone response difference tcr gene rearrangements szczepanski blot analysis leukemic sample van wering disease course 3 rearrangements dh-jh selection germline t-cell cancer wolvers-tettero ilm incidence oligoclonality n 363s polymorphism sequencing exon 5 intron bcli polymorphism