Chiche, L.

receptor residue promoter binding wild-type position expression zinc cluster transcription androgen activation position 564 plasmid transcription activation wild-type ar alanine residue probe cho cells protein library erasmus mc mutation activity assay promoter interference assay cluster dna binding alanine androgen receptor luciferase substitution study wild-type receptor aspartic acid residue presence reporter acid substitutions r 1881 acid residues receptor protein luciferase activity modeling histidine hormone absence structure glucocorticoid patient domain element cotransfected trapman j asparagine transfected data point mmtv promoter ar dbd histidine residue van rooij hcj response leucine conformation interference dna-binding aspartic analysis transiently transfected backbone leucine residue index patient erasmu t test sequence acid residue luciferase assay expression plasmid vivo dna binding transcriptional transiently 1 mm edta 564l transcription activation