Leeuwen, F.W. van

ubb +1 protein ubi-b ␤ app ϩ1 proteasome expression ubb +1 accumulation accumulation ubb +1 expression level inhibitor cortex patient culture control inhibition ␤ app disease slice deletion ups inhibition mutation ubb +1-positive cells ubb +1 protein reporter result transcript vector ubg 76v ubiquitin expression levels system science ubi-b ϩ1 immunoreactivities substrate neuron ds patients genomic degradation clone leeuwen primer proteasome inhibitor ups activity transduction 36 hours ubi-b ϩ1 proteins cortex slice cultures lindsten ϩ1 proteins treatment section dinucleotide pcdna activity gfp reporter fischer property proteasome inhibitors cell lines proteasome inhibition organotypic percentage tangle transfected ubi-b ϩ1 immunoreactivity tet-off genomic pcr ubi-b ϩ1 exons 9 cortex cultures neuropil threads journal dinucleotide deletions immunoreactivity motif nondemented nucleotide inducible ubiquitin-proteasome system