Veghel-Plandsoen, M. van

mutation cancer breast cancer brca 1 brca 2 mutations family breast chek 2*1100delc patient analysis individual 2*1100delc identi fied deletion control identi variant ratio probe chek 2 sequence fication 1.5 cylindromatosi 0.5 2.5 unclassi fied variant genetic netherland frequency index patient rearrangement genet duplication syndrome index result allele mosaic product figure breast cancer risk chromosome brooke-spiegler syndrome identi fication table carrier brca 2 mosaicism tuberous sclerosis sample exon 20 trichoepithelioma breast cancer unselected nature research susceptibility unclassi speci father group marker breakpoint tsc 2 linkage parent sensitivity sequence analysis brooke-spiegler protein 1100 delc mutation duplication-speci fic pcr breast cancer susceptibility study change chek 2*1100delc variant detection van den ouweland population primer speci fic