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peptide t cells target t lymphocytes lymphocytes target cells transfer speci clone response ctl clones ebv-speci transduced -296 receptor t 2 cells tumor antigen chain melanoma donor hla-a ebv-speci fic tcr tcr gene transfer t cells transduced expression assay cytotoxic cytolytic transduction erasmus university rotterdam ctl-mpd gp 100 peptide tctcrab ctl -296 ebna -3b specificity cancer tcr-transduced fl-mpd immunol jurkat jurkat t cells tcr genes efficiency molecule cytolytic efficiencies ratio gene transfer peptide-loaded target cells tetramer bolhui /o pept binding b-lcl level virus 30 min re-targeted t cells flow cytometry transductant 100po cd 28 domain activation epstein-barr mutant fi nal concentration fl -296 tcrpos anti-tcrvb region cdr 3 regions patient t lymphocytes transduced tcr-transduced t lymphocytes position speci fic anti-tcrv university disease
3 Most Recent Publications
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T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production
(Article)
Schaft, N. Lankiewicz, B. Bolhuis, R.L.H. Willemsen, R.A. Debets, J.E.M.A. Drexhage, H.A. Berrevoets, C.A. Moss, D.J. Levitsky, V. Bonneville, M. Lee, S.P. McMichael, A.J. Gratama, J-W. |
2006-04-01
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Redirecting Human T Cells to Tumors via Transfer of T Cell Receptor Genes: a study of tumor-specific T cell responses and peptide fine-specificity
(Doctoral Thesis)
Schaft, N. |
2003-06-05
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Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes
(Article)
Schaft, N. Willemsen, R.A. Vries, J. de Lankiewicz, B. Essers, B.W. Gratama, J-W. Figdor, C.G. Bolhuis, R.L.H. |
2003-01-01
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