Zijlstra, A.J.E.

-65 slp -65 pre-b k 430r kinase pre-b cells b cells slp -65 mice function expression b-cell pre-b-cell protein tumor suppressor tumor suppressor tyrosine double-deficient activity tyrosine kinase k 430r mice activation development level figure pre-bcr b cell development calcium phosphorylation bruton k 430r transgene adaptor j biol chem number tumor suppressor function btk kinase activity b-cell development btk-deficient kinase-inactive btk plc 2 absence kinase-inactive defect wild-type background pi 3k kinase activity adaptor molecule btk-deficient mice immunol pathway serum stage differentiation slp -65. marrow blood immunity embo j block wild-type btk membrane serum ig levels igm /igd profiles flow cytometric analysis k 430r expression 20 b cells stimulation kinase-inactive k 430r splenic b cells middendorp j exp med slp -65 background result lymphoma btk-deficient mice .18 dingjan gm pre-bcr stimulation molecule finding