Portielje, J.E.

-12 il -12 rhuil patient effect injection level interleukin cytokine administration -10 production il -10 cancer range interleukin -12 rhuil -12 rhuil -12 injection plasma concentration 0.5 study blood induction tumor necrosis factor il -12 administration baseline increment -12. immunol t cells 7 days il -8 rhuil -12. 1 g /kg subset leukocyte tumor count antitumor effects 0.5 g /kg lymphocyte response plasma levels monocyte nk cells cell cancer phase 0.1 down-regulation neutrophils plasma concentrations il -6 0.1 g /kg antitumor il -12 administrations 1.25 g /kg baseline levels lymphocytes factor cytotoxic t cells sample result interleukin 12 receptor number expression il -12. blood leukocyte subsets phase i study il -12 production il -8 production il -12 receptor rhuil -12 injections necrosis lymphocyte subsets 26 patients killer cells leukocyte subsets reduction