Roth, R.B.

agent alkylating activity chemotherapeutic alkylating agents mtase cancer mgmt –/– mice repair –/– tissue alkylating agents chemotherapeutic mouse erasmus university rotterdam methyltransferase 6-meg marrow 6-methylguanine figure wild-type hematopoietic 6-meg dna mtase bone marrow cells figure 2 b natl acad level animal treatment –/– mice effect protein sensitivity mgmt –/– mefs 6-methylguanine methyltransferase mgmt ϩ/ϩ result resistance temozolomide ficient 6-alkylguanine alkyltransferase lindahl university carcinogenesi erasmu mtase activity tumor 6-alkylguanine alkyltransferase knockout bone marrow samson rotterdam moritz dna repair protein downloaded sakumi extract gerson march alkylation analysis identi fied dna damage hematopoietic tissues sekiguchi liver glycosylase expression escherichia coli antitumor activity fragment allele number cancer institute ablation ludlum control bamhi margison toxicity