http://hdl.handle.net/1765/10021




Value of coronary stenotic flow velocity acceleration in prediction of angiographic restenosis following balloon angioplasty


Article
volume 23, issue 23 pp 1849-1853.
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INTRODUCTION: Quantitative angiographic assessment after balloon angioplasty is a poor predictor of immediate and long-term outcome. However, the measurement of blood flow velocity during angioplasty has been proved clinically useful. AIMS: To analyse the value of the maximal stenotic flow velocity and the presence of stenotic flow velocity acceleration (aSV) for the long-term outcome after balloon angioplasty. METHODS AND RESULTS: Patients undergoing single lesion angioplasty within the DEBATE trial were included. aSV was defined as acceleration in the stenotic coronary flow velocity >50% baseline velocity assessed at a reference site of the target vessel. After balloon angioplasty diameter stenosis, minimal lumen diameter (MLD) and coronary flow velocity reserve were similar between the aSV (n=54) and non-aSV group (n=125). At follow-up, the aSV group had a higher restenosis rate (52% vs 30%, P=0.006) The presence of aSV was the strongest independent predictor of restenosis (OR 3.08, 95% CI 1.35 to 7.05, P=0.008). The best predictive cut-off value of SV was 101cm.s(-1) (sensitivity of 46%, specificity of 81%, positive predictive value of 85% and a negative predictive value of 58%). CONCLUSION: Following angioplasty, SV appears to be exquisitely sensitive to the changes experienced at the treated area without depending on the status of the microcirculation.



Keywords


Automatically Extracted Terms
  • velocity
  • angioplasty
  • flow velocity reserve
  • restenosi
  • patient
  • value
  • 6- month follow-up
  • group
  • follow-up
  • angiographic
  • reserve
  • measurement
  • balloon angioplasty
  • study
  • stenosi
  • presence
  • doppler
  • diameter
  • balloon
  • stenotic


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