In Vivo and in Vitro Studies on the Localisation and Kinetics of Porphyrin Related Drugs for Photodetection and Photodynamic Therapy
(In vivo en in vitro studies naar de lokalisatie en kinetiek van porfyrine-achtige stoffen voor fotodetectie en fotodynamische therapie)
2003-11-13
Doctoral Thesis
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Photodetection and photodynamic therapy (PDT) of malignant and premalignant skin lesions are based on the activation of a photosensitive drug (photosensitiser) with (laser) light. The ideal photosensitiser accumulates selectively in the (pre)malignant tissue. Upon illumination with light of an appropriate wavelength, the photosensitiser fluoresces and reacts with cellular substances and/or produces singlet oxygen. This is causing cell death and thus destruction of the (pre)- malignant tissue. The fluorescent properties can also be used for diagnosis of (pre)malignant tissue, which is not visible for the eye. The photodynamic properties can induce undesired side effects like prolonged skin photosensitivity and erythema. The starting point of this thesis was to evaluate the use of other agents than porphyrin derivatives or protoporphyrin IX (PpIX) for photodetection purposes in order to avoid undesired side effects which are related to the use of photodynamically active drugs.
Levendag, Prof. Dr. P.C. (promotor)
Biolitec Pharma ltd
Brown, Prof. Dr. S.B. (promotor)
European Community (grant BMH4-CT97-2260)
Galderma Nederland
Harlan Nederland
NDDO Oncology
Novartis Ophthalmics, the Netherlands
Radium Hospital Research Foundation
Willem H. Kroger Foundation
Yorkshire Cancer Research
- application
- fluorescence
- mouse skin
- alahe
- stratum corneum
- 5- aminolevulinic acid
- penetration
- mouse
- photodynamic therapy
- lesion
- production
- ester
- study
- aminolevulinic
- stratum
- corneum
- ppix production
- photodynamic
- figure
- esters
