Molecular-genetic insights in pediatric T-cell acute lymphoblastic leukemia
(Moleculair genetische inzichten in T-cel acute lymfatische leukemie bij kinderen)
2008-04-17
Doctoral Thesis
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T-ALL is an aggressive T-cell malignancy with an inferior treatment outcome compared to B-lineage ALL. Intensive T-ALL research efforts during the last years lead to the identification of multiple genetic abnormalities that cooperate in the malignant transformation of thymocytes. Currently and in contrast to B-lineage ALL, genetic abnormalities are clinically not used for therapy stratification. Further progress on the treatment of T-ALL will require further genetic characterization, which will provide us with a better understanding of the pathogenesis of T-ALL and hopefully will lead to improved treatment schedules. As the general scope of this thesis, we performed genome-wide copy number analysis using array-CGH for the identification of novel genomic rearrangements in T-ALL that possibly relate to treatment outcome, i.e. prognostic factors, or provide further insight in the pathogenesis of T-cell leukemia.
Pieters, Prof. Dr. R. (promotor),
Sophia Foundation for Medical Research (SSWO grant 404)
- t-all
- patient
- leukemia
- t-cell
- expression
- deletion
- mutation
- lymphoblastic leukemia
- analysis
- lymphoblastic
- figure
- notch
- region
- genomic
- activation
- lmo 2
- chapter
- t-all patients
- t-all cases
- abnormality
