Antibody response after influenza immunization with various vaccine doses
1993-03-19
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The dose effect (0, 10, 20 and 60 micrograms) of influenza subunit vaccine on the antibody response was investigated in nursing-home residents and young controls. The vaccine antigens were: A/Taiwan/1/86 (H1N1), A/Sichuan/2/87 (H3N2) and B/Beijing/1/87. For the influenza B antigen, the post-GMT and the 'percentage protective titre' increased significantly both in the young controls and nursing-home residents. No dose effect was observed for the A/Taiwan, and a minor dose effect for A/Sichuan. All vaccine doses were well tolerated by both groups. We conclude from our data that higher vaccine doses may result in a better antibody response against some antigens but not against others. Therefore, in general, increasing the vaccine dose is no adequate method to improve the antibody response.
- Male
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Middle Aged
- Adolescent
- Antibodies, Viral/*biosynthesis
- Dose-Response Relationship, Immunologic
- Nursing Homes
- Double-Blind Method
- Influenza A virus/immunology
- Influenza B virus/immunology
- Antigens, Viral/administration & dosage
- Influenza Vaccines/*administration & dosage/adverse effects
- vaccine
- influenza
- centre
- response
- study
- nursing-home residents
- antibody response
- antibody
- group
- antigen
- nursing-home
- resident
- difference
- value
- percentage
- vaccination
- age group
- subject
- study centres
- influenza vaccine
