(Pro)Renin Uptake and Prorenin Activation in the Cardiovascular System
((Pro)renine opname en prorenine activatie in het cardiovasculaire systeem)
1998-12-17
Doctoral Thesis
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Traditionally the renin-angiotensin system (RAS) has been viewed as a circulating system. Circulating renin, released by the kidneys, cleaves liver-derived angiotensinogen, which yields the inactive decapeptide angiotensin I (Ang (1-10) or Ang I) (Figure 1). Ang I is subsequently converted into an octapeptide, angiotensin II (Ang (1-8) or Ang II), by angiotensin-converting enzyme (ACE), an enzyme that is either located at the huninal side of the endothelium or circulating freely in plasma. Ang II is rapidly metabolized by so-called angiotensinases.
Supervisors
(promotores):
The
author
wishes to thank:
Netherlands Heart Foundation,
Dr Saal van Zwanenberg Foundation
Keywords
Automatically Extracted Terms
- renin
- prorenin
- receptor
- angiotensin
- medium
- effect
- ang ii
- phosphate
- tissue
- fibroblast
- incubation
- heart
- activation
- binding
- cardiomyocyte
- concentration
- angiotensin ii
- protein
- level
- mannose
