Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
September 2009
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Background: Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and in the blue nevi of the skin.Methods:GNAQ exon 5 was amplified from 75 ciliary body and choroidal melanoma DNAs and sequenced directly. GNAQ mutation status was correlated with disease-free survival (DFS), as well as other clinical and histopathological factors, and with chromosomal variations detected by FISH and CGH.Results:Of the 75 tumour DNA samples analysed, 40 (53.3%) harboured oncogenic mutations in GNAQ codon 209. Univariate and multivariate analysis showed that GNAQ mutation status was not significantly correlated with DFS.Conclusion:The GNAQ mutation status is not suitable to predict DFS. However, the high frequency of GNAQ mutations may render it a promising target for therapeutic intervention.
- adult
- article
- female
- human
- male
- aged
- priority journal
- controlled study
- prediction
- unclassified drug
- human tissue
- gene mutation
- cancer survival
- Survival
- exon
- chromosome 3
- comparative genomic hybridization
- histopathology
- disease free survival
- tumor volume
- DNA sequence
- gene amplification
- fluorescence in situ hybridization
- correlational study
- DNA determination
- Oncogenic mutation
- Uveal melanoma
- choroid melanoma
- chromosome 8q
- chromosome variant
- ciliary body tumor
- codon
- guanine nucleotide binding protein alpha subunit Q
- guanine nucleotide binding protein alpha subunit
